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Marsha Rivkin Center for Ovarian Cancer Research
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Working Group Meeting

Marsha Rivkin Center Working Group

Every other week, since 1996, the Marsha Rivkin Center has hosted a Working Group Meeting that is attended by doctors and scientists from leading medical facilities such as Fred Hutchinson Cancer Research Center, Swedish Medical Center, the University of Washington, Virginia Mason Medical Center, and Pacific Northwest Research Institute.

The most critical problems in ovarian cancer research are identified and discussed, resulting in important scientific collaborations. The meetings are open to all researchers, physicians, post-docs and advocates in the field of ovarian cancer.

The Working Group Meeting takes place at Swedish Medical Center, Conference Room 1-East (PDF map). All meetings begin at 7 a.m.

Upcoming Meetings:

Aug 8, 2006
Piri Welcsh, PhD (Univ. of Washington)
Title: "Pilot Study Final Report: Epigenetic Profiling of Ovarian Cancer with High-Density Microarrays"
Aug 22, 2006
Cassian Yee, MD (FHCRC)
Title: "Pilot Study Final Report: Identification of T cell-defined Antigens in Ovarian Cancer"

Members & Recent Presentations:

Nicole Urban, ScD, Charles Drescher, MD, Saul Rivkin, MD, Ingegerd Hellstrom, MD, PhD, Karl Erik Hellstrom, MD, PhD, Nathalie Scholler, MD, PhD, Michel Schummer, PhD, Patty Theiss, RN, PhD, Garnet Anderson, PhD, Shirley Gough, RN, Kathy O'Briant, Robert Resta, MS; Brad Nelson, PhD; Brad Stone, PhD; Nancy Kiviat, MD; Nora Disis, MD; Bruce Montgomery, MD; Robyn Andersen, PhD; Martin McIntosh, PhD; Eric Lynch, PhD
Jul 11, 2006
Nicole Urban, ScD and Charles Drescher, MD (FHCRC)
Title: "Early Lesion Discovery Project"
And Nathalie Scholler, MD, PhD (FHCRC)
Title: "Development of a CA125-Mesothelin Cell Adhesion Assay as a Screening Tool for Biologics Discovery"
Jun 27, 2006
Saul Rivkin, MD (Swedish Medical Center & Marsha Rivkin Center)
Title: "ASCO Update"
Jun 13, 2006
Judeth Bianco, RPh, PhD (Novartis)
Title: "Preclinical and Clinical Overview of Patupilone (EPO906) : A Novel Epothilone Currently in Phase III Trials for Refractory/Resistant Ovarian Cancer"
May 23, 2006
Saul Rivkin, MD (Swedish Medical Center & Marsha Rivkin Center)
Title: "Evaluation of New Ovarian Cancer Markers in Relation to Clinical Practice and Early Relapse"
May 9, 2006
Nicole Urban, ScD; Charles Drescher, MD and Michel Schummer, PhD (FHCRC)
Title: "HE4 staining of prophylactic oophorectomy specimens"
Apr 25, 2006
*CANCELLED*
Apr 11, 2006
Sarah Holt, MPH (Univ. of Washington)
Title: "Ovarian Cancer Risk and Polymorphisms Involved in Estrogen Catabolism - Final Report"
Mar 28, 2006
Jen-Tsan Ashley Chi (Duke University)
Title: "Genomic Analysis of Hypoxia Phenotypes in Human Cancers"
Mar 14, 2006
Charles Drescher (FHCRC)
Discussion: Recent Early Detection Publications
Feb 28, 2006
Ingegerd Hellstrom, MD, PhD (UW)
Title: "Preliminary studies on Ovarian Carcinoma Stem cells"
Feb 14, 2006
Nicole Urban, ScD and Charles Drescher, MD (FHCRC)
Title: TBD
Jan 24, 2006
Tony Blau, MD (UW)
Title: TBD
Jan 10, 2006
Barbara Goff, MD (Univ of Washington) and Robyn Andersen, PhD (FHCRC)
Final Report: Ovarian Cancer Symptom Study
Dec 27, 2005
*CANCELLED*
Dec 13, 2005
Robyn Andersen, PhD (FHCRC)
Title: TBD
Nov 22, 2005
Muneesh Tewari, MD, PhD (FHCRC)
Title: "Networks, tumor robustness and evolution: potential relevance to cancer biology and therapy"
Nov 8, 2005
Hootie Warren, MD, PhD (FHCRC)
Title: "A polymorphic oncofetal antigen recognized by CD8+ CTL from two patients with metastatic RCC responding to nonmyeloablative allogeneic HCT."
Oct 25, 2005
Update: 13th Annual SPORE Meeting (Baltimore, WA)
Discussion led by Saul Rivkin, MD (Swedish Medical Center)
Oct 11, 2005
Marci Schaner, PhD (Pfizer)
Title: "Update of Genomic Profiling in Ovarian Cancer"
Sep 27, 2005
Update: Helene Harris Memorial Trust Conference
Discussion Led by Nicole Urban, ScD (FHCRC)
Sep 13, 2005
Zsolt Petko, MD (FHCRC)
Title: TBD
Aug 23, 2005
Andre Lieber, MD (Univ. of Washington)
Title: "Challenges for oncolytic virotherapy of ovarian cancer"
Aug 9, 2005
Ruey-Min Lee, PhD (Huntsman Cancer Institute, Univ of Utah)
Title: "Induction of cell death by targeting mitochondrial proteins as a novel cancer therapy"
Jul 26, 2005
Prof. Michal Linial (Hebrew Univ. of Jerusalem & Visiting Professor at UW)
Title: "Snapshots of living cells - A Bioinformatics Approach"
Jul 12, 2005
*CANCELLED*
June 28, 2005
Robert Resta, MS, CGC (SMC)
Title: "Screening for BRCA Mutations in Ashkenazi Jews: A Possible Research Project"
June 7, 2005
David Huntsman (Univ. of British Columbia)
Study Final Report: EMSY amplification: clinical relevance in ovarian cancer
May 17, 2005
Bruce Montgomery, MD (VA Puget Sound)
Title: TBD
May 3, 2005
Daniela Dinulescu, PhD (MIT Center for Cancer Research)
Title: "Genetic Models of Endometriosis and Ovarian Cancer"
Apr 19, 2005
Beatrice Knudsen, PhD (FHCRC)
Title: "Identifying the cellular origin of serous ovarian cancer: Expression profiles associated with early ovarian carcinogenesis"
Apr 5, 2005
Ellen Pizer, MD (SMC) and Pamela Paley, MD (SMC)
Discussion: "Pilot Project for Detection of Early Pathologic and Molecular Alterations"
Mar 15, 2005
Ellen Pizer, MD (SMC)
Title: "Precursor lesions of serous carcinoma"
Mar 1, 2005
Title: "Oral contraceptives in reducing the risk of ovarian cancer in BRCA positive women"
Discussion led by Robert Resta
Feb 15, 2005
Saul Rivkin, MD (SMC & MRC)
Title: "Update on Oncovue: A Risk Assessment Product"
Feb 1, 2005
Irena King, PhD (FHCRC)
Title: "The Role of N-3 (Omega-3) Fatty Acids on Ovarian Cancer Progression and Survival"
Jan 18, 2005
Irena King, PhD (FHCRC)
Title: "The Effect of N-3 (Omega-3) Fatty Acids on Ovarian Cancer Recurrence/Progression"
Jan 4, 2005
Charles Drescher, MD (FHCRC & MRC)
Title: "The Marsha Rivkin Center Ovarian Cancer Screening Program- a proposal"
Dec 21, 2004
*Cancelled*
Dec 7, 2004
Nathalie Scholler, MD, PhD (FHCRC)*
Title: TOR Lab Update
* Dr. Hanash will be rescheduling for February
Nov 16, 2004
Toshiyasu Taniguchi, MD, PhD (FHCRC)
Title: "The Fanconi Anemia-BRCA Pathway in Cancer"
Nov 2, 2004
Jeff Ross, MD (Millennium Pharmaceuticals Inc.)
Title: "Emerging Molecular Diagnostics and Targets of Therapy in Ovarian Cancer"
Oct 19, 2004
Literature Discussion: BRCA and ovarian cancer
Oct 5, 2004
TBD
Sep 21, 2004
Dr. Hua Mu (Abraxis Oncology)
Topic: Nano-Particle Technology
Sep 7, 2004
Nicole Urban, ScD & Charles Drescher, MD
Screening Studies: Future Plans
Aug 17, 2004
Discussion Topic: RNA Extraction (Continued)
Aug 3, 2004
Discussion Topic: RNA Extraction
Papers available by contacing Jocelyn Moore at jocelyn.moore@swedish.org.
Jul 20, 2004
Saul Rivkin, MD (SMC & MRC)
Discussion: 12th Annual SPORE Meeting Review
Jul 6, 2004
Biaoyang Lin, PhD
Title: "Identification of chemotherapy response related proteins in ovarian cancer by a proteomics approach"
June 15, 2004
Brad Stone, PhD (Benaroya Research Center, Virginia Mason)
Title: TBD
June 1, 2004
Kathy O'Briant, MS (FHCRC)
Title: "Preliminary Luminex Results"
May 18, 2004
Jeff Ledbetter, PhD (Trubion Inc.)
Title: "Genes and Gene Delivery Systems for Cancer Therapy"
April 20, 2004
Shaoyi Jiang, PhD (UW)
Title: "Surface Plasmon Resonance Biosensor for Medical Diagnostics"
April 6, 2004
Irena King, PhD (FHCRC)
Title: "Ovarian Cancer Recurrence -
What's fat got to do with it?"
March 16, 2004
Alvin Liu, PhD (Institute of Systems Biology)
Title: "Prostate Cell Lineages"
March 2, 2004
Brad Stone, PhD (VM)
Title: TBD
February 17, 2004
Daniel Egger (Factorial Diagnostics)
Title: TBD
February 3, 2004
Discussion: "Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2," King et al, Science, Vol 302 pp643 - 646.
Discussion led by Robert Resta, MS, CGC
(Swedish Medical Center)
Please contact Jocelyn Moore at jocelyn.moore@swedish.org for copies of article.
January 20, 2004
Anna Lokshin, PhD (Univ. of Pittsburgh)
Title: "Multiplex Serum Assay for Early Detection of Ovarian Cancer"
December 16, 2003
Dominic Andrada M.S. (Bio-Rad Labs)
Title: "BioPlex: Multiplexed Protein Flow Cytometric Analysis "
December 2, 2003
Ellen Pizer, MD (Swedish Medical Center)
Title: TBD
November 18, 2003
Daniel O'Shannessy, MD (Fujirebio Diagnostics)
Title: Progress towards the early detection of ovarian cancer
November 4, 2003
Kathryn McGonigle, MD (Virginia Mason)
Title: Surgical management of ovarian cancer
October 21, 2003
Michél Schummer, PhD (MacroGenics)
Title: Molecular Profiling of Ovarian Tissues
October 7, 2003
Patrice Morin, PhD (National Institutes of Health)
Title: Expression profiling in ovarian cancer: identification of novel genes and pathways for diagnosis and therapy
September 16, 2003
Sharon Moran, MD (Virginia Mason)
Title: Microarray expression analysis of human tumor antigens in ovarian cancer
September 2, 2003
Eric Lynch, PhD (Vice-President, Sound Pharmaceuticals, Inc.)
Title: "Chemoprotection from cisplatin induced hearing loss"
August 19, 2003
Lupe Salazar, MD (Univ. of Washington)
Title: "Phase I study evaluating the safety of three doses of intraperitoneal DAB389IL-2 (ONTAK) administered to patients with advanced stage ovarian cancer"
*Specially Scheduled Working Group Meeting*
  August 12, 2003
Thomas Herzog, MD (Washington Univ. School of Medicine)
Title: "New Directions in the Treatment of Ovarian Cancer"
This meeting is sponsored by GlaxoSmithKline. Continental breakfast will be provided.
August 5, 2003
Andre Lieber, MD, PhD (Univ. of Washington)
Title: "Oncolytic adenoviruses for treatment of metastatic cancer"
*Special Working Group Meeting*
  Jul 29, 2003
David Curiel, MD (Univ. of Alabama at Birmingham)
Title: "Strategies to adapt adenovirus for cancer therapy application"
Jul 15, 2003
TBD
Jul 1, 2003
Charles Drescher, MD (FHCRC)
Title: "Using Molecular Profiling for Selecting Therapy"
June 17, 2003
Nicole Urban, ScD (FHCRC)
Title: "Design Issues in Chemoprevention Trials in Ovarian Cancer"
June 3, 2003
Denise C. Connolly, Ph.D. (Fox Chase Cancer Center)
Title: "Modeling epithelial ovarian cancer in mice"
May 20, 2003
Eleftherios P. Diamandis MD, PhD, FRCPC (University of Toronto)
Title: "Presentation of Kallikrein Family of Markers and Their Role in Ovarian Cancer"
May 6, 2003
Howard Muntz, MD (Virginia Mason Medical Center)
Title: "Intraperitoneal Consolidation Therapy for Advanced Ovarian Cancer"
April 15, 2003
Toni Kline, PhD (Seattle Genetics)
Title: "Matrix Metalloproteases for the Targeting and Release of Antitumor Agents"
Apr 1, 2003
Julianne Wojciak, MS, CGC (Myriad Genetic Laboratories)
Title: "Hereditary Breast and Ovarian Cancer: An Update of Recent Publications"
Mar 18, 2003
Barbara Goff, MD (UW) and Robyn Andersen, MPH, PhD (FHCRC)
Title: "Evaluating Symptoms as a Biomarker for Ovarian Cancer"
Mar 4, 2003
Qinghua Feng, PhD (UW)
Title: "Epigenetic Changes in Ovarian Cancer"
Feb 18, 2003
David Ralph, PhD & Craig Shimasaki, PhD (InterGenetics Inc., Oklahoma City, OK)
Title: "Statistical dissection of the role of genetics in determining risk of complex diseases"
For more information contact Jocelyn Moore at (206) 215-6202
Feb 4, 2003
Keith Knutson, MD (UW)
Title: "Immune-based approaches for the treatment and prevention of cancer"
Jan 21, 2003
Discussion:
  • Couzin, Jennifer, "Small RNAs Make Big Splash," Science vol 298, Dec 20, 2002 pp. 2296-2297.
  • Plasterk, Ronald, "RNA Silencing: The Genome's Immune System," Science vol 296, May 17, 2002 pp. 1263 - 1265.

Please contact Jocelyn Moore at jocelyn.moore@swedish.org or (206) 215-6202 to request copies of articles

Jan 7, 2003
Udo Schmeidl, MD (SMC)
Title: "RFA (Radio Frequency Ablation) of liver masses"
Dec 10, 2002
Mark Murray (Protiva Inc., Vancouver, BC)
Title: "Tumor-Selective Gene Expression and Anti-tumor Activity Following Systemic Gene Delivery with Stable Plasmid Lipid Particles"
Nov 26, 2002
Shahram Vaezy, PhD (UW)
Title: "Tumor Treatment using High Intensity Focused Ultrasound"
Nov 12, 2002
Neli Ulrich, PhD (FHCRC)
Concept proposal: "Pharmacogenetics of platinum-based therapy in ovarian cancer patients"
Oct 29, 2002
Brad Nelson, PhD (VMRC) & Ingegerd Hellstrom, MD, PhD (PNRI)
Mouse Models for Ovarian Carcinoma
Oct 15, 2002
Biaoyang Lin (Institute for Systems Biology)
A systems approach to study the androgen-response program in prostate cancer cells
Oct 1, 2002
Richard Kneirim, MD (SMC)
"Mucinous Neoplasms of the Ovary"
Sept 17, 2002
Dr. Roohangiz Safaei (Univ. of Calif. San Diego)
"ID of Organelles and Molecules Invovled in Cisplatin Resistance in Ovarian Cancer Cells"
Sept 3, 2002
Charles Drescher & Nicole Urban (FHCRC, MRC)
Strategic Planning for the Marsha Rivkin Center
August 20, 2002
Larry Kessler, ScD (FHCRC Visiting Scientist & FDA)
"Regulatory Requirements for Genetic Tests and Biomarkers"
August 6, 2002
Michèl Schummer, PhD (MacroGenics)
"Towards clinical applications of genes found to be associated with chemoresistance in ovarian cancer"
June 25, 2002
Ingegerd Hellstrom, MD, PhD (PNRI)
"Approaches to tumor vaccination"
June 11, 2002
Patty Theiss, PhD (VMRC)
"CD4+ CD8+ T cells specific for epitopes expressed in mice ovarian tumors do not proliferate after encountering the ovarian tumor in vivo"
May 28, 2002
Cassian Yee, MD (FHCRC & UW)
"Adoptive T Cell Therapy of Cancer"
May 14, 2002
Karin Rodland & Colleagues (PNNL)
"Pacific Northwest National Laboratories Proteomics Capabilities, Plasma Proteome Project scFV Antibody Capability, Development of Bead Based Assays, Mass Spectrometry and Biochemical Separations"
April 30, 2002
Robyn Andersen, PhD, MPH (FHCRC)
"Quality of Life Intervention for Breast and Ovarian Cancer Patients"
April 16, 2002
Mark Hannibal, MD, PhD (Univ. of Wash.)
"Replacing high-dose cytotoxic agents by allogeneic graft versus host effects in the cure of cancer"
April 2, 2002
Martin McIntosh, PhD (FHCRC) & Nicole Urban, ScD (FHCRC)
Discussion: "Use of proteomic patterns in serum to identify ovarian cancer." Lancet 359: 572 - 577, 2002 Feb 16.
March 19, 2002
David Paisley, MD (Swedish Medical Center)
"PET scans and the evaluation of ovarian cancer patients"
March 5, 2002
Rainer Storb, MD (FHCRC)
"Replacing high-dose cytotoxic agents by allogeneic graft versus host effects in the cure of cancer"
February 19, 2002
Discussion & Planning: "4th Biennial Ovarian Cancer Symposium: Sept 19 - 20, 2002"
February 5, 2002
Alan Wahl, PhD and Nathalie Scholler, MD, PhD (Seattle Genetics)
"Antibody-targeted therapies for cancer"
January 22, 2002
Paul Weiden, MD & Jelle Kylstra, MD (Dendreon Corporation)
"HER2 Targeted Cellular Therapies in Ovarian and Breast Cancer"
January 8, 2002
Discussion: Shridhar V, et. al.
"Genetic analysis of early- versus late-stage ovarian tumors." Cancer Research. 61(15):5895-904, 2001 Aug 1.

For more information, please contact Jocelyn Moore at jocelyn.moore@swedish.org.